Methamphetamine Induces Anhedonic-Like Behavior and Impairs Frontal Cortical Energetics in Mice.

نویسندگان

  • Raquel Fonseca
  • Rui A Carvalho
  • Cristina Lemos
  • Ana C Sequeira
  • Inês R Pita
  • Fábio Carvalho
  • Carlos D Silva
  • Rui D S Prediger
  • Ivana Jarak
  • Rodrigo A Cunha
  • Carlos A Fontes Ribeiro
  • Attila Köfalvi
  • Frederico C Pereira
چکیده

INTRODUCTION We recently showed that a single high dose of methamphetamine (METH) induces a persistent frontal cortical monoamine depletion that is accompanied by helpless-like behavior in mice. However, brain metabolic alterations underlying both neurochemical and mood alterations remain unknown. AIMS Herein, we aimed at characterizing frontal cortical metabolic alterations associated with early negative mood behavior triggered by METH. Adult C57BL/6 mice were injected with METH (30 mg/kg, i.p.), and their frontal cortical metabolic status was characterized after probing their mood and anxiety-related phenotypes 3 days postinjection. RESULTS Methamphetamine induced depressive-like behavior, as indicated by the decreased grooming time in the splash test and by a transient decrease in sucrose preference. At this time, METH did not alter anxiety-like behavior or motor functions. Depolarization-induced glucose uptake was reduced in frontocortical slices from METH-treated mice compared to controls. Consistently, astrocytic glucose transporter (GluT1) density was lower in the METH group. A proton high rotation magic angle spinning (HRMAS) spectroscopic approach revealed that METH induced a significant decrease in N-acetyl aspartate (NAA) and glutamate levels, suggesting that METH decreased neuronal glutamatergic function in frontal cortex. CONCLUSIONS We report, for the first time, that a single METH injection triggers early self-care and hedonic deficits and impairs frontal cortical energetics in mice.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

BDNF-Deficient Mice Show Reduced Psychosis-Related Behaviors Following Chronic Methamphetamine

BACKGROUND One of the most devastating consequences of methamphetamine abuse is increased risk of psychosis. Brain-derived neurotrophic factor has been implicated in both psychosis and neuronal responses to methamphetamine. We therefore examined persistent psychosis-like behavioral effects of methamphetamine in brain-derived neurotrophic factor heterozygous mice. METHODS Mice were chronically...

متن کامل

[Depressive-like state and sleep in laboratory mice].

In order to induce the state of anhedonia, a key symptom of depression, mice were subjected to a one-month stress procedure comprised of various stressors. Anhedonic state was defined by a reduction of preference for sucrose solution over tap water. Conventional cortical and neck-muscle electrodes were implanted to control and stressed animals under chloral-hydrate anesthesia. After a two-week ...

متن کامل

A Stereological Study on Hippocampal Subfields Following Administration of Methamphetamine in Male Mice

Background and Aims: This study examined sub-chronic effects of Methamphetamine (METH) on the stereological parameters in the Cornu Ammonis (CA) of the hippocampus in adult mice. Materials and Methods: Fifteen adult male mice, eight weeks old, were randomly divided into three groups: receive saline (controls), or low-dose (LD) 2.5 mg/kg METH, or high-dose (HD) 25 mg/kg METH, via daily intrap...

متن کامل

Frontal Lobe Contusion in Mice Chronically Impairs Prefrontal-Dependent Behavior.

Traumatic brain injury (TBI) is a major cause of chronic disability in the world. Moderate to severe TBI often results in damage to the frontal lobe region and leads to cognitive, emotional, and social behavioral sequelae that negatively affect quality of life. More specifically, TBI patients often develop persistent deficits in social behavior, anxiety, and executive functions such as attentio...

متن کامل

Glutamatergic Neurometabolites during Early Abstinence from Chronic Methamphetamine Abuse

BACKGROUND The acute phase of abstinence from methamphetamine abuse is critical for rehabilitation success. Proton magnetic resonance spectroscopy has detected below-normal levels of glutamate+glutamine in anterior middle cingulate of chronic methamphetamine abusers during early abstinence, attributed to abstinence-induced downregulation of the glutamatergic systems in the brain. This study fur...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • CNS neuroscience & therapeutics

دوره 23 2  شماره 

صفحات  -

تاریخ انتشار 2017